PittsburghV1, Canada, Analysis, bibRecord, 000284

Relationship Between Alcohol Use Categories and Noninvasive Markers of Advanced Hepatic Fibrosis in HIV-Infected, Chronic Hepatitis C Virus-Infected, and Uninfected Patients

Identifieur interne : 000284 ( Canada/Analysis ); précédent : 000283; suivant : 000285

Relationship Between Alcohol Use Categories and Noninvasive Markers of Advanced Hepatic Fibrosis in HIV-Infected, Chronic Hepatitis C Virus-Infected, and Uninfected Patients

Auteurs : Joseph K. Lim [États-Unis] ; Janet P. Tate [États-Unis] ; Shawn L. Fultz [États-Unis] ; Joseph L. Goulet [États-Unis] ; Joseph Conigliaro [États-Unis] ; Kendall J. Bryant [États-Unis] ; Adam J. Gordon [États-Unis] ; Cynthia Gibert [États-Unis] ; David Rimland [États-Unis] ; Matthew Bidwell Goetz [États-Unis] ; Marina B. Klein [Canada] ; David A. Fiellin [États-Unis] ; Amy C. Justice [États-Unis] ; Vincent Lo Iii Re [États-Unis]

Source :

Clinical infectious diseases [ 1058-4838 ] ; 2014.

RBID : Pascal:14-0141725

Descripteurs français

Pascal (Inist)
- Fibrose hépatique, SIDA, Hépatite virale C, Alcool, Virus hépatite C, Homme.
Wicri :
- topic : Alcool, Homme.

English descriptors

KwdEn :
- AIDS, Alcohol, Hepatic fibrosis, Hepatitis C virus, Human, Viral hepatitis C.

Abstract

Background. It is unclear if the risk of liver disease associated with different levels of alcohol consumption is higher for patients infected with human immunodeficiency virus (HIV) or chronic hepatitis C virus (HCV). We evaluated associations between alcohol use categories and advanced hepatic fibrosis, by HIV and chronic HCV status. Methods. We performed a cross-sectional study among participants in the Veterans Aging Cohort Study who reported alcohol consumption at enrollment (701 HIV/HCV-coinfected; 1410 HIV-monoinfected; 296 HCV-monoinfected; 1158 HIV/HCV-uninfected). Alcohol use category was determined by the Alcohol Use Disorders Identification Test-Consumption (AUDIT-C) questionnaire and alcohol-related diagnoses and was classified as nonhazardous drinking, hazardous/binge drinking, or alcohol-related diagnosis. Advanced hepatic fibrosis was defined by FIB-4 index >3.25. Results. Within each HIV/HCV group, the prevalence of advanced hepatic fibrosis increased as alcohol use category increased. For each alcohol use category, advanced hepatic fibrosis was more common among HIV-infected than uninfected (nonhazardous: 6.7% vs 1.4%; hazardous/binge: 9.5% vs 3.0%; alcohol-related diagnosis: 19.0% vs 8.6%; P<.01) and chronic HCV-infected than uninfected (nonhazardous: 13.6% vs 2.5%; hazardous/binge: 18.2% vs 3.1%; alcohol-related diagnosis: 22.1% vs 6.5%; P<.01) participants. Strong associations with advanced hepatic fibrosis (adjusted odds ratio [95% confidence interval]) were observed among HIV/HCV-coinfected patients with nonhazardous drinking (14.2 [5.91-34.0]), hazardous/binge drinking (18.9 [7.98-44.8]), and alcohol-related diagnoses (25.2 [10.6-59.7]) compared with uninfected nonhazardous drinkers. Conclusions. Advanced hepatic fibrosis was present at low levels of alcohol consumption, increased with higher alcohol use categories, and was more prevalent among HIV-infected and chronic HCV-infected patients than uninfected individuals. All alcohol use categories were strongly associated with advanced hepatic fibrosis in HIV/HCV-coinfected patients.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001286

Affiliations:

Links to Exploration step

Pascal:14-0141725

Le document en format XML

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<author><name sortKey="Goetz, Matthew Bidwell" sort="Goetz, Matthew Bidwell" uniqKey="Goetz M" first="Matthew Bidwell" last="Goetz">Matthew Bidwell Goetz</name>
<affiliation wicri:level="2"><inist:fA14 i1="09"><s1>VA Greater Los Angeles Healthcare System and David Geffen School of Medicine at UCLA</s1>
<s2>Los Angeles, California</s2>
<s3>USA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Klein, Marina B" sort="Klein, Marina B" uniqKey="Klein M" first="Marina B." last="Klein">Marina B. Klein</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Chronic Viral Illness Service, McGill University Health Centre</s1>
<s2>Montreal</s2>
<s3>CAN</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fiellin, David A" sort="Fiellin, David A" uniqKey="Fiellin D" first="David A." last="Fiellin">David A. Fiellin</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Yale University School of Medicine</s1>
<s2>New Haven, Connecticut</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="11"><s1>Yale Center for Interdisciplinary Research on AIDS, Yale School of Public Health</s1>
<s2>New Haven, Connecticut</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Justice, Amy C" sort="Justice, Amy C" uniqKey="Justice A" first="Amy C." last="Justice">Amy C. Justice</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Veterans Affairs (VA) Connecticut Healthcare System</s1>
<s2>West Haven</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Veterans Affairs (VA) Connecticut Healthcare System</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Yale University School of Medicine</s1>
<s2>New Haven, Connecticut</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="11"><s1>Yale Center for Interdisciplinary Research on AIDS, Yale School of Public Health</s1>
<s2>New Haven, Connecticut</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Re, Vincent Lo Iii" sort="Re, Vincent Lo Iii" uniqKey="Re V" first="Vincent Lo Iii" last="Re">Vincent Lo Iii Re</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Philadelphia VA Medical Center and Perelman School of Medicine, University of Pennsylvania</s1>
<s3>USA</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Philadelphia VA Medical Center and Perelman School of Medicine, University of Pennsylvania</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Clinical infectious diseases</title>
<title level="j" type="abbreviated">Clin. infect. dis.</title>
<idno type="ISSN">1058-4838</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Clinical infectious diseases</title>
<title level="j" type="abbreviated">Clin. infect. dis.</title>
<idno type="ISSN">1058-4838</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term>
<term>Alcohol</term>
<term>Hepatic fibrosis</term>
<term>Hepatitis C virus</term>
<term>Human</term>
<term>Viral hepatitis C</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Fibrose hépatique</term>
<term>SIDA</term>
<term>Hépatite virale C</term>
<term>Alcool</term>
<term>Virus hépatite C</term>
<term>Homme</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Alcool</term>
<term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background. It is unclear if the risk of liver disease associated with different levels of alcohol consumption is higher for patients infected with human immunodeficiency virus (HIV) or chronic hepatitis C virus (HCV). We evaluated associations between alcohol use categories and advanced hepatic fibrosis, by HIV and chronic HCV status. Methods. We performed a cross-sectional study among participants in the Veterans Aging Cohort Study who reported alcohol consumption at enrollment (701 HIV/HCV-coinfected; 1410 HIV-monoinfected; 296 HCV-monoinfected; 1158 HIV/HCV-uninfected). Alcohol use category was determined by the Alcohol Use Disorders Identification Test-Consumption (AUDIT-C) questionnaire and alcohol-related diagnoses and was classified as nonhazardous drinking, hazardous/binge drinking, or alcohol-related diagnosis. Advanced hepatic fibrosis was defined by FIB-4 index >3.25. Results. Within each HIV/HCV group, the prevalence of advanced hepatic fibrosis increased as alcohol use category increased. For each alcohol use category, advanced hepatic fibrosis was more common among HIV-infected than uninfected (nonhazardous: 6.7% vs 1.4%; hazardous/binge: 9.5% vs 3.0%; alcohol-related diagnosis: 19.0% vs 8.6%; P<.01) and chronic HCV-infected than uninfected (nonhazardous: 13.6% vs 2.5%; hazardous/binge: 18.2% vs 3.1%; alcohol-related diagnosis: 22.1% vs 6.5%; P<.01) participants. Strong associations with advanced hepatic fibrosis (adjusted odds ratio [95% confidence interval]) were observed among HIV/HCV-coinfected patients with nonhazardous drinking (14.2 [5.91-34.0]), hazardous/binge drinking (18.9 [7.98-44.8]), and alcohol-related diagnoses (25.2 [10.6-59.7]) compared with uninfected nonhazardous drinkers. Conclusions. Advanced hepatic fibrosis was present at low levels of alcohol consumption, increased with higher alcohol use categories, and was more prevalent among HIV-infected and chronic HCV-infected patients than uninfected individuals. All alcohol use categories were strongly associated with advanced hepatic fibrosis in HIV/HCV-coinfected patients.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Connecticut</li>
<li>District de Columbia</li>
<li>Géorgie (États-Unis)</li>
<li>Maryland</li>
<li>Pennsylvanie</li>
<li>Québec</li>
<li>État de New York</li>
</region>
<settlement><li>Montréal</li>
<li>Washington (district de Columbia)</li>
</settlement>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Lim, Joseph K" sort="Lim, Joseph K" uniqKey="Lim J" first="Joseph K." last="Lim">Joseph K. Lim</name>
</noRegion>
<name sortKey="Bryant, Kendall J" sort="Bryant, Kendall J" uniqKey="Bryant K" first="Kendall J." last="Bryant">Kendall J. Bryant</name>
<name sortKey="Conigliaro, Joseph" sort="Conigliaro, Joseph" uniqKey="Conigliaro J" first="Joseph" last="Conigliaro">Joseph Conigliaro</name>
<name sortKey="Fiellin, David A" sort="Fiellin, David A" uniqKey="Fiellin D" first="David A." last="Fiellin">David A. Fiellin</name>
<name sortKey="Fiellin, David A" sort="Fiellin, David A" uniqKey="Fiellin D" first="David A." last="Fiellin">David A. Fiellin</name>
<name sortKey="Fultz, Shawn L" sort="Fultz, Shawn L" uniqKey="Fultz S" first="Shawn L." last="Fultz">Shawn L. Fultz</name>
<name sortKey="Gibert, Cynthia" sort="Gibert, Cynthia" uniqKey="Gibert C" first="Cynthia" last="Gibert">Cynthia Gibert</name>
<name sortKey="Goetz, Matthew Bidwell" sort="Goetz, Matthew Bidwell" uniqKey="Goetz M" first="Matthew Bidwell" last="Goetz">Matthew Bidwell Goetz</name>
<name sortKey="Gordon, Adam J" sort="Gordon, Adam J" uniqKey="Gordon A" first="Adam J." last="Gordon">Adam J. Gordon</name>
<name sortKey="Goulet, Joseph L" sort="Goulet, Joseph L" uniqKey="Goulet J" first="Joseph L." last="Goulet">Joseph L. Goulet</name>
<name sortKey="Goulet, Joseph L" sort="Goulet, Joseph L" uniqKey="Goulet J" first="Joseph L." last="Goulet">Joseph L. Goulet</name>
<name sortKey="Justice, Amy C" sort="Justice, Amy C" uniqKey="Justice A" first="Amy C." last="Justice">Amy C. Justice</name>
<name sortKey="Justice, Amy C" sort="Justice, Amy C" uniqKey="Justice A" first="Amy C." last="Justice">Amy C. Justice</name>
<name sortKey="Justice, Amy C" sort="Justice, Amy C" uniqKey="Justice A" first="Amy C." last="Justice">Amy C. Justice</name>
<name sortKey="Lim, Joseph K" sort="Lim, Joseph K" uniqKey="Lim J" first="Joseph K." last="Lim">Joseph K. Lim</name>
<name sortKey="Re, Vincent Lo Iii" sort="Re, Vincent Lo Iii" uniqKey="Re V" first="Vincent Lo Iii" last="Re">Vincent Lo Iii Re</name>
<name sortKey="Rimland, David" sort="Rimland, David" uniqKey="Rimland D" first="David" last="Rimland">David Rimland</name>
<name sortKey="Tate, Janet P" sort="Tate, Janet P" uniqKey="Tate J" first="Janet P." last="Tate">Janet P. Tate</name>
<name sortKey="Tate, Janet P" sort="Tate, Janet P" uniqKey="Tate J" first="Janet P." last="Tate">Janet P. Tate</name>
</country>
<country name="Canada"><region name="Québec"><name sortKey="Klein, Marina B" sort="Klein, Marina B" uniqKey="Klein M" first="Marina B." last="Klein">Marina B. Klein</name>
</region>
</country>
</tree>
</affiliations>
</record>

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Relationship Between Alcohol Use Categories and Noninvasive Markers of Advanced Hepatic Fibrosis in HIV-Infected, Chronic Hepatitis C Virus-Infected, and Uninfected Patients

Relationship Between Alcohol Use Categories and Noninvasive Markers of Advanced Hepatic Fibrosis in HIV-Infected, Chronic Hepatitis C Virus-Infected, and Uninfected Patients

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